Ulcerative Colitis and Limb Loss: A Case Report
Leila Ghahramani
1
,
Abbas Rezaianzadeh
2
,
Sam Moslemi
1
, *
,
Salar Rahimikazerouni
1
and
Seyed Vahid Hosseini
1
1 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Health Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
*
Sam Moslemi, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-7112306972, E-mail:
moslemis@sums.ac.ir
Scimetr: April 30, 2014, 2 (2) ; e87364
Published Online :
March 30, 2014
Article Type: Case Report
Received:
January 24, 2014
Accepted:
February 01, 2014
DOI : 10.5812/scimetr.17813
To Cite:
Ghahramani
L , Rezaianzadeh
A , Moslemi
S , Rahimikazerouni
S, Hosseini
S V . Ulcerative Colitis and Limb Loss: A Case Report,
Scimetr.
2014
; 2(2):e87364.
doi: 10.5812/scimetr.17813 .
Abstract
Introduction: Protein C is a precursor of a vitamin K-dependent serine protease, which is activated by thrombin in the presence of
Case Presentation: A 33-year old woman with acute exacerbation of ulcerative colitis was found to have protein C deficiency (serum protein C activity estimated as 35% of the normal activity). Protein C deficiency was diagnosed after the onset of several arterial thromboemboli complications (brachiocephalic and popliteal artery thrombosis) during her hospital admission for exacerbation of ulcerative colitis (UC). Therefore, upper limb below elbow and lower limb below knee amputation were performed for her.
Conclusions: After total proctocolectomy, serum protein C activity remained as 35% of the normal activity, so the patient used warfarin as lifelong anticoagulant. Investigation of other family members revealed normal thrombophilia screening tests.
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